Research Overview

Mechanism-driven therapeutic discovery.

We develop chemical strategies that respond to disease-associated biological signals and translate these responses into selective drug release, amplified pharmacological activity, and improved therapeutic outcomes.

Research Areas

Four connected directions.

Responsive Prodrug Chemistry

We design prodrug systems that respond to disease-relevant chemical and biological signals.

  • Self-immolative linker chemistry
  • ROS-responsive drug release
  • Payload-adaptable prodrug platforms

Tumor Microenvironment-Responsive Therapeutics

We exploit abnormal features of the tumor microenvironment to achieve selective activation and localized drug action.

  • Tumor-selective molecular activation
  • Redox-regulated therapeutic response
  • Mechanism-based antitumor evaluation

Antibody-Drug Conjugates and Targeted Delivery

We explore linker and payload designs for targeted systems with controlled release and improved compatibility.

  • ADC linker development
  • Non-classical payload conjugation
  • Microenvironment-triggered release

Click-to-Release Chemical Platforms

We develop click-to-release chemical platforms that enable bioorthogonal and controllable activation of functional molecules in complex biological systems.

  • Bioorthogonal click-to-release chemistry
  • Chemical biology tools and molecular probes
  • Controlled activation and payload release

Research Platforms

Chemistry and biology in one workflow.

Chemistry

  • Organic synthesis and molecular design
  • Linker and prodrug construction
  • Structure–activity relationship studies
  • Analytical characterization

Biology

  • Cell-based pharmacological evaluation
  • Drug release and activation studies
  • Mechanism validation
  • In vivo efficacy and safety evaluation

Research Philosophy

Design with a testable mechanism.

We believe that effective drug discovery requires a clearly defined biological problem, a chemically testable mechanism, and a rational path toward translational development. Our long-term goal is to connect molecular design, disease biology, and therapeutic application.