Responsive Prodrug Chemistry
We design prodrug systems and self-immolative linkers that respond to disease-relevant chemical signals, including oxidative stress and redox imbalance.
Zheng Lab ยท China Pharmaceutical University
Medicinal Chemistry, Chemical Biology, and Translational Drug Discovery.
Zheng Lab focuses on the design and development of mechanism-driven therapeutic strategies at the interface of medicinal chemistry, chemical biology, prodrug design, targeted drug delivery, and click-to-release chemistry.
We aim to create functional molecular systems that respond to disease-associated biological signals and translate these responses into selective drug release, amplified pharmacological activity, and improved therapeutic outcomes.
Research Areas
Mechanism-driven chemistry for more precise therapeutics.
Tumor Microenvironment-Responsive Therapeutics
We develop therapeutic strategies that exploit abnormal features of the tumor microenvironment to achieve selective activation and localized drug action.
Antibody-Drug Conjugates and Targeted Delivery
We explore linker, payload, and conjugation strategies for targeted therapeutics, with emphasis on controlled release and payload compatibility.
Click-to-Release Chemical Platforms
We develop bioorthogonal click-to-release systems, chemical biology tools, and molecular probes for controlled activation and mechanistic studies.
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Research Philosophy
Clear biological questions. Testable chemical mechanisms.
We believe that effective drug discovery requires a clearly defined biological problem, a chemically testable mechanism, and a rational path toward translational development. Our long-term goal is to establish original chemical platforms that connect molecular design, disease biology, and therapeutic application.